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Meg Ryan has posted a tribute to the departed filmmaker Rob Reiner, under whose direction she worked in the hit romantic comedy When Harry Met Sally.

A Heartbreaking Event

Reiner was located lifeless with his wife, Michele Singer Reiner, at their residence in LA this past weekend.

“Oh how we will miss this man…” Ryan shared on Instagram, alongside a picture of them together. “We thank you, Rob and Michele, for your belief in true love, fairy tales, and laughter. Your trust in people's goodness and your love for this nation are remembered.”

Court Case Developments

Reiner’s son Nick, 32, faces two counts of first-degree murder and was in court today. He’s being detained without the option of bail. Reports indicate that Reiner’s daughter Romy discovered her father deceased.

“I have to believe that their story will not end with this impossible tragedy, that some good may come, some awareness raised,” Ryan continued. “Perhaps they would desire a legacy of hope and humanity, leading us toward empathy and tranquility.”

Children Share Their Grief

Reiner’s other children Jake and Romy issued words today. “Language fails to capture the daily agony we endure,” they said. “The tragic, shattering loss of our parents is an experience no one should have to face. They weren’t just our parents; they were our best friends.”

Peers Pay Their Respects

Ryan’s co-star, Billy Crystal, similarly honored Reiner with a statement shared yesterday along with names including Larry David, Martin Short and Albert Brooks.

“His comedic touch was beyond compare, his love of getting the music of the dialogue just right, and his sharpening of the edge of a drama was simply elegant,” the statement said. “For the actors, he loved them. For the writers he made them better. His finest trait was granting creative liberty. He valued input and made you part of the team. They always felt they were working as a team. To be in his hands as a film-maker was a privilege but that is only part of his legacy.”

A Storied Career

When Harry Met Sally was a box office and critical triumph in 1989, grossing more than $93 million worldwide and earning Nora Ephron an Oscar nomination for best original screenplay.

Rob Reiner met Michele Singer Reiner during the production of When Harry Met Sally. The pair were brought together by Barry Sonnenfeld, a fellow filmmaker and pal.

Reiner’s extensive filmography featured classics such as Misery, Stand by Me and The Princess Bride. The director and his wife were husband and wife for over three decades.